Effect of eugenol on animal models of nociception

Department of Pharmacology, Objective: To investigate the antinociceptive potential of eugenol on different pain models Bharati Vidyapeeth Deemed in mice. University, Poona College of Pharmacy, Materials and Methods: Eugenol was evaluated (1-100 mg/kg, i.p.) in various Pune 411 038. experimentally induced pain models like, formalin induced hyperalgesia, acetic acid *Present Address: Discovery induced abdominal constrictions, and thermal pain experiment using Eddy’s hot plate. Biology, Advinus Therapeutics, Results: Eugenol significantly inhibited acetic acid induced abdominal constrictions, Bioresearch Centre, with the maximal effect (92.73% inhibition) at 100 mg/kg. In formalin induced paw Pune 411057, licking pain model, eugenol exhibited more pronounced antinociceptive effect in the Maharashtra, India. inflammatory phase than the neurogenic phase (maximal effect was 70.33% and 42.22%, respectively, at 100 mg/kg, i.p). A mild reduction in the pain response latency at 100 Received: 31.3.2006 mg/kg, i.p. dose of eugenol was observed in the hotplate thermal pain studies in mice. Revised: 28.6.2006 Accepted: 3.7.2006 In the rotarod motor coordination experiment eugenol reduced the endurance time at the dose of 100 mg/kg, i.p. Correspondence to: Conclusion: The data suggest that eugenol exerts antinociceptive activity in different S.L. Bodhankar experimental models of pain in mice. E-mail: [email protected]